MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #1 How some probiotic scientists are working to address COVID-19Read more...
MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #2 Using Probiotics to Flatten the Curve of Coronavirus Disease COVID-2019 PandemicRead more...
MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #3 According to a research team at Ehwa Womans University Medical Center, it has confirmed...Read more...
MeridLife Powder and Capsule Probiotics Two of the hottest selling daily probiotics in Taiwan: TOTAL:flora Senior Probiotic+Prebiotic...Read more...
MeridLife Pet ALL-IN-ONE Hip & Joint w/Multivitamins Powder MeridLife Pets Specialty Formula Hip & Joint supplement for your dog and cat. Sprinkle the…Read more...
COSTCO Taiwan demo for new Kid’s Calcium Effervescent Powder Drink MeridLife President & Co-Owner Richie Walker assisting the CDS Demo lady while launching…Read more...
MeridLife Specialty Formula Senior Probiotic Our new MeridLife Senior Probiotic + Prebiotic Yogurt Flavored powder special…Read more...
MeridLife COSTCO Shanghai Hip & Joint Tablets MeridLife Glucosamine & Chondroitin + Calcium Tablets for Hip & Joint health in Costco...Read more...
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Costco Taiwan Roadshow We were previously known as Meridian before changing our brand name to MeridLife...Read more...
MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #1
How some probiotic scientists are working to address COVID-19 May 4, 2020/in ISAPP Science Blog, News / By ISAPP board of directors
With the global spread of COVID-19, the scientific community has experienced an unusual interruption. Across every field, many laboratories are temporarily shuttered and research programs of all sizes are on hiatus.
In this global circumstance of research being put on hold, it is enlightening to consider what some scientists in the fields of probiotics, prebiotics, and fermented foods are working on the context of understanding ways to combat viral threats with PROBIOTICS.
Here, ISAPP shares words from some of these scientists—and how they have connected the dots from probiotics to coronavirus-related work with potential medical relevance.
Drs. Paul Wischmeyer and Anthony Sung, Duke University School of Medicine, USA: Probiotics for prevention or treatment of COVID-19 infection
We have conducted several randomized clinical trials of probiotics in COVID-19 prevention and treatment. These trials are based on multiple clinical trials and meta-analyses that have shown that probiotics may reduce upper and lower respiratory tract infections, sepsis, and ventilator associated pneumonia by 30-50%.
These benefits are due to the beneficial effects of probiotics on the immune system. The Wischmeyer laboratory and others have shown that probiotics, such as Lactobacillus rhamnosus, can improve intestinal/lung barrier and homeostasis, increase regulatory T cells, improve anti-viral defense, and decrease pro-inflammatory cytokines in respiratory and systemic infections. These clinical benefits are especially relevant to individuals who have developed, or are at risk of developing COVID-19.
COVID-19 has been characterized by severe lower respiratory tract illness, and patients may manifest an excessive inflammatory response similar to cytokine release syndrome, which has been associated with increased complications and mortality. We hypothesize that probiotics will directly reduce COVID-19 infection risk and severity of disease/symptoms.
We will conduct a multicenter, randomized trial of the probiotic Lactobacillus rhamnosus vs. placebo to decrease infections and improve outcomes. This trial will utilize a commercial probiotic, delivering 20 billion CFU of Lactobacillus rhamnosus.
As the world waits in ‘lockdown’ mode, continued scientific progress for coronavirus prevention or treatment with Probiotics is critically important. All probiotic and prebiotic scientists are stepping up to pursue unique solutions.
Prof. Sarah Lebeer, University of Antwerp, Belgium:
Could the microbes in our upper and lower airways play a role in how we respond to the virus? Significant individual differences exist in the microbes that are prevalent and dominant in our airways. Lactobacilli are found in the respiratory tract, especially in the nasopharynx.
They might originate there from the oral cavity via the oronasopharynx, but we have found some strains that seem to be more adapted to the respiratory environment, for example by expressing catalase enzymes to withstand oxidative stress.
For many years we have studied a different virus, namely rotavirus, that causes acute diarrhea in children, and have found that Lactobacillus rhamnosus binds rotavirus and disables it, thereby blocking viral infection/multiplication.
Prof. Rodolphe Barrangou, North Carolina State University, USA: Engineering probiotic lactobacilli for vaccine development
Between NC State University and Colorado State University (CSU) there is a historical collaborative effort aiming at engineering probiotics to develop novel vaccines. The intersection of probiotics and antivirals is the focus here with expressing antigens on the cell surface of probiotics to develop oral vaccines.
We are actively engineering Lactobacillus acidophilus probiotics expressing COVID-19 proteins to be tested as potential vaccines at CSU in the near future, as progress dictates.
MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #2
Despite strategies based on social distancing, hygiene, and screening, COVID-19 is progressing rapidly throughout the world, with healthcare systems at risk of being overwhelmed. While identification of effective drug therapies is ongoing, vaccines will not be available in the near future. Therefore, additional preventive strategies are urgently needed.
COVID-19 presents with a spectrum of disease severity, ranging from mild and non-specific flu-like symptoms, to pneumonia. Coronaviruses, including SARS-Cov-2 can invade enterocytes, thereby acting as a reservoir for the virus (4). Indeed, large clinical studies from China indicate that gastrointestinal symptoms are common in COVID-19, and are associated with disease severity (3, 4).
Probiotics are live microorganisms that when administered in adequate amounts confer a health benefit on the host. Clinical evidence shows that certain probiotic strains help to prevent bacterial and viral infections, including gastroenteritis, sepsis, and respiratory tract infections (RTIs). The reason for adding probiotic strains to the overall prevention and care strategy is founded in science and clinical studies.
Clinical Data Supporting the Use of Probiotics to Prevent Covid-19
Probiotics can prevent antibiotic-associated diarrhea, and infections in the gastrointestinal tract, but also infections at other sites, including sepsis.
A randomized placebo-controlled intervention study of 479 adults showed that Lactobacillus gasseri, Bifidobacterium longum with vitamins and minerals lowered not only the duration of common cold episodes but also days with fever. The impact of probiotics on prevention of upper RTI’s caused by specific viruses has also been documented.The incidence of influenza RTI was reduced following consumption of Lactobacillus brevis in an open label study of 1,783 school children.
Pertinent to the pandemic affecting adults more than children, these positive findings were confirmed in an RCT that included 27 elderly subjects receiving Bifidobacterium longum or placebo. Furthermore, lactic acid bacteria, from which many probiotics are selected, are part of the upper respiratory tract microbiota in healthy people, and some strains are being considered for prevention of recurrent otitis media. This makes their use for contributing to slow down progression of the coronavirus pandemic worthy of consideration.
The following are examples of probiotic strains with documentation in human studies that may have relevance in reducing the effects and burden of theCovid-19 pandemic.
Basis for inclusion
When to administer
Reduced incidence and duration of RTIs
Once daily for duration of the pandemic
Lactobacillus gasseri , Bifidobacterium longum
Lowering duration and severity of flu-like illness
Once daily for duration of the pandemic
For digestive health and gut barrier integrity, and prevention of viral RTIs
One capsule daily for duration of the pandemic
Prevention of upper RTIs, immune modulation
2 g sachet per day for duration of pandemic
Basis for inclusion
When to administer
Bifidobacterium breve and Lactobacillus casei
Lower incidence of ventilator-associated pneumonia
Pediococcus pentosaceus , Leuconostoc mesenteroides, L. paracasei, L. plantarum plus inulin,
To reduce rate of SIRS, infections, sepsis, days of stay in the intensive care unit, days under mechanical ventilation, and mortality
For COVID-19 patients
Mechanistic Basis for the Action of Probiotics to Prevent Infections and Relevance to Covid-19
Mechanisms that might explain clinical success of probiotics include enhancement of the intestinal epithelial barrier, competition with pathogens for nutrients and adhesion to the intestinal epithelium, production of anti-microbial substances and modulation of the host immune system. Bifidobacterium bifidum and Streptococcus thermophilus reduced the incidence of diarrhea and shedding of rotaviruses.
Safety of Probiotics Probiotics are generally safe, even in the most vulnerable populations and in intensive care settings.Rather than consider intensive care patients too ill to receive probiotic and prebiotic therapy, RCTs of probiotics for the prevention of ventilator-associated pneumonia provide a reason to consider them.
SummaryIn summary, the orally administered probiotic strains of Lactobacillus gasseri, Bifidobacterium longum, Lactobacillus gasseri (L. gasseri) and Lactobacillus rhamnosus can reduce the incidence and severity of viral RTIs. At a time when doctors are using drugs with little anti- COVID-19 data, probiotic strains documented for anti-viral and respiratory activities should become part of the strategy to reduce the burden and severity of this pandemic.
Government funding is being used to test numerous drugs but just as important, they should fund probiotic trials. In addition, use of recognized prebiotics to enhance propagation of probiotic strains and indigenous beneficial microbes should be recommended as part of the overall strategy to flatten the Covid -19 curve.
MERIDLIFE NEW RESEARCH: RESEARCH ANALYSIS #3
According to a research team at Ehwa Womans University Medical Center, it has confirmed probiotic bacteria extracted from fermented sea buckthorn berry had lots of lactobacillus gasseri (L. gasseri), which represses the activation of purine, an energy source required for the mutation of new coronavirus.
The group of researchers found L. gasseri while conducting experiments related to the inhibition of cytokine activity, and escherichia coli that inflame the bladder.
The researchers, led by Professor Yoon Ha-na of the Urology Department, also discovered that sea buckthorn berry had abundant amounts of ehstreptococcus thermophilus and lactobacillus rhamnosus, which have the same chemical binding site to the COVID-19 and affect the protein activity of AIDS. They also confirmed nine antioxidants, six minerals, and 16 amino acids.
Professor Yoon expects the probiotic bacteria (L. gasseri) found in sea buckthorn berry to be a supplementary treatment to suppress COVID-19 spread by inhibiting purine activity.
“I believe the probiotic bacteria will work as a complementary treatment to prevent COVID-19 and will apply the same mechanism to additional studies, including cystitis and hyperlipidemia,” Professor Yoon said.
MeridLife Powder and Capsule Probiotics
Two of the hottest selling daily probiotics in Taiwan: TOTAL:flora Senior Probiotic+Prebiotic Yogurt Flavor Oral Powder and TOTAL Probiotic Capsules for family. Available in PX Mart Taiwan, WATSONS and your favorite health supply store.
MeridLife Pet ALL-IN-ONE Hip & Joint w/Multivitamins Powder
MeridLife Pets Specialty Formula Hip & Joint supplement for your dog and cat. Sprinkle the powder over your pet’s meal and let them enjoy the taste and health benefits that alleviates hip & joint pain and offers cartilage support and mobility wellness. Available only in Costco Taiwan.
MeridLife Pets Specialty Formula for Hip & Joint wellness and mobility in the ½ LB size. Available in PX Mart Taiwan and your favorite pet store.
COSTCO Taiwan demo for new Kid’s Calcium Effervescent Powder Drink
MeridLife President & Co-Owner Richie Walker assisting the CDS Demo lady while launching new Kid’s Calcium Effervescent Drink Powder is a Costco Taiwan warehouse. Great tasting Green Apple and Orange flavored Kid’s Calcium is available in all Costco Taiwan warehouses and on Costco Taiwan e-commerce site.
A Costco member sampling our new Kid’s Calcium Effervescent Drink Powder.
New MeridLife Kid’s Calcium stacked high in Costco Taiwan.
MeridLife Specialty Formula Senior Probiotic
Our new MeridLife Senior Probiotic + Prebiotic Yogurt Flavored powder special formula for Adults 55+. This Senior focused Probiotic is available in all Costco Taiwan locations and Costco Taiwan e-commerce site.
MeridLife COSTCO Shanghai Hip & Joint Tablets
MeridLife Glucosamine & Chondroitin + Calcium Tablets for Hip & Joint health in Costco Shanghai.
Pet Show Taipei Jul 2017
MeridLife CEO Richie Walker holding our Dog Glucosamine & Chondroitin Hip and Joint and the Ultra Skin & Coat at Taipei International Pet Show July 2017
MeridLife CEO Richie Walker with our top selling Dog Glucosamine & Chondroitin with Multivitamins Hip & Joint Supplement.
A happy customer in Taipei with our Dog Glucosamine & Chondroitin for canine buddy at Taipei International Pet Show, July 2017.
Two lovely pet owners with our Dog Glucosamine & Chondroitin at the Taipei International Dog Show.
Costco Taiwan Roadshow
We were previously known as Meridian before changing our brand name to MeridLife. Here you see photos of our highly successful 'Roadshows' displaying our products in all Costco Taiwan warehouses.